BindingDB BDBM50328584 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one::CHEMBL1256459

BDBM50328584 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one::CHEMBL1256459

SMILES CCC(=O)N1CCN(CC1)c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1

InChI Key InChIKey=AKCRNFFTGXBONI-UHFFFAOYSA-N

Data 14 IC50 3 Kd 2 EC50

Found 1 hit for monomerid = 50328584

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 564nMAssay Description:Inhibition of P110delta/p85-alphaMore data for this Ligand-Target Pair

Targets 14▿
- Serine/threonine-protein kinase mTOR 5
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Phosphatidylinositol 4-kinase alpha 1
- Serine/threonine-protein kinase MRCK alpha 1
- Target of rapamycin complex 2 subunit MAPKAP1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- DNA-dependent protein kinase catalytic subunit 1
- Target of rapamycin complex subunit LST8 1
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
Publications 3▿
- J Med Chem 53: 7146-55 (2010) 15
- J Med Chem 54: 1473-80 (2011) 2
- J Med Chem 61: 4656-4687 (2018) 2
Institutions 2▿
- Dana-Farber Cancer Institute 17
- China Pharmaceutical University 2
Affinity: 0.29 to 1.0E+4 nM▿
- IC50 14
- Kd 3
- EC50 2
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1